Alternative method to regenerate bone using Platelet rich fibrin membrane
원영헌, 김지형, 김홍석, 김수관, 문성용,
소속 상세정보
원영헌 ( Won Young-Hun ) - Chosun University Graduate School Department of Dentistry
김지형 ( Kim Ji-Hyoung ) - Chosun University Graduate School Department of Dentistry
김홍석 ( Kim Hong-Seok ) - Chosun University Graduate School Department of Dentistry
김수관 ( Kim Su-Gwan ) - Chosun University School of Dentistry Department of Oral and Maxillofacial Surgery
문성용 ( Moon Seong-Yong ) - Chosun University School of Dentistry Department of Oral and Maxillofacial Surgery
KMID : 0353420160400040179
Abstract
The purpose of this study was to evaluate PRF membrane for the rabbit calvarial bone defect in terms of new bone formation and the histological changes. Twelve skeletally mature New Zealand white male rabbits, weighing from 2.5 to 3.0 kg, were used in this study. Four equal 8 mm diameter bone defects were created in each rabbit. Subsequently, the rabbits were divided into four groups including Group I, control group without any treatment; Group II, grafted with Bongros® (Bioalpha Inc, Seongnam, Korea); Group III, grafted with Bongros® and covered with collagen membrane (Bio-gide®, Geistch, Switzerland); and Group IV, grafted with Bongros® and covered with PRF membrane. Micro CT, histologic, and histomorphometric analyses were performed at 2, 4, and 8 weeks for evaluation of defects. The results showed a significant increase in histomorphometric bone area; in addition, micro CT analysis showed significant increase in new bone formation in Groups II, III, and IV, as compared to Group I (control). However, new bone formation showed no significant differences between Groups II, III, and IV. Bio-Gide was seen at 2 and 4 weeks but not at 8 weeks; likewise, PRF membrane was seen at 2 and 4 weeks but not at 8 weeks. The application of PRF at the initial bone healing has a favorable effect. PRF includes high concentrations of growth factors. Thus, PRF has advantages in bone regeneration due to its osteoinductive ability.
키워드
Alloplastic bone; Bone graft; Collagen membrane; Guided bone regeneration; Platelet rich fibrin (PRF)
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